Background: Non-steroidal anti-inflammatory drugs (NSAIDs) are frequently used for pain, fever, and inflammation. They are readily accessible over-the-counter (OTC) in community pharmacies without a prescription. Due to the ease with which NSAIDs can be acquired, selfmedication with NSAIDs is an increasing concern as it may result in inappropriate use, leading to drug-related problems and potentially serious adverse effects. Objective: The main purpose of this study was to assess the general public’s current level of knowledge, attitude, perception, and practice regarding the use of OTC NSAIDs, to explore their perspective regarding receiving information on NSAIDs, and also to determine the relationship between the knowledge, attitude, perception, and practice. Methods: A cross-sectional study was conducted among the general public in Selangor who had self-medicated with oral OTC NSAIDs. A structured, validated questionnaire was distributed electronically in community pharmacies and via social media platforms. In addition, a hard copy of the questionnaires was provided for non tech-savvy participants. Respondents were recruited through convenience sampling. Incomplete responses were excluded. Data was analysed using Statistical Package for Social Sciences (SPSS). Results: A total of 358 respondents completed the survey. Findings suggest that overall, the general public in Selangor demonstrated good knowledge (70.95%), positive attitude (PRR=67.88%), and good practice (PRR=58.75%) towards OTC NSAIDs use. However, perception of NSAID risks was poor (PRR=35.64%), especially related to risks of selfmedicating and sharing of NSAIDs among friends and family. Age, gender, and education levels were key determinants affecting knowledge levels. Most respondents (89.39%) showed a positive perspective towards receiving information on NSAIDs, with 94.14% agreeing that healthcare professionals (HCPs) should play a direct role in providing such information Statistically significant positive correlations were observed between knowledge-attitude (r=0.218, p<0.001), knowledge-perception (r=0.294, p<0.001), knowledge-practice (r=0.294, p<0.001), attitude-perception (r=0.270, p<0.001), attitude-practice (r=0.585, p<0.001) and perception-practice (r=0.385, p<0.001). Conclusion: There were potential gaps and misconceptions identified in certain areas, particularly regarding the safety aspects of NSAIDs. The study recommends targeted educational interventions to raise awareness and improve overall medication safety. Keywords: NSAIDs, painkillers, community pharmacy, health, wellbeing