Publication: ASSOCIATION OF GENOTYPES AND HAPLOTYPES OF TUMOUR NECROSIS FACTOR –ALPHA (TNF-α) WITH OVERWEIGHT/OBESITY-RELATED PHENOTYPES IN MALAYSIAN POPULATION
| dc.contributor.author | NUR ASHIKIN BINTI AZEMI | |
| dc.date.accessioned | 2023-10-06T15:32:12Z | |
| dc.date.available | 2023-10-06T15:32:12Z | |
| dc.date.issued | 2018 | |
| dc.description.abstract | Background: Obesity is classified as low-grade chronic inflammatory disease and genetic predisposition may play a role in the susceptibility to obesity development. Previous studies have shown that pro-inflammatory cytokine, TNF-α promoter region polymorphism was associated with overweight/obesity in various population. Therefore, this study aims to investigate the association of three single nucleotide polymorphisms of TNF-α (G-308A, C-863A and G-238A) and their haplotypes with the risk of overweight/ obesity in Malaysian population. Methods: Classification of overweight/obesity followed the Malaysian Clinical Practice Guideline of Obesity (2004). Polymorphisms of TNF-α (G-308A, C-863A and G-238A) were evaluated on 105 overweight/obese subjects and 100 non-overweight/ non-obese subjects as controls through tetra-arms PCR. Chi square and logistic regression analysis were done using SPSS software while haplotype and linkage disequilibrium analysis were done using HaploView 4.2 software. Results: The rare A alleles of TNF-α G-308A, C-863A and G-238A did not occur more frequently in overweight/obese individual as compared to controls. Similar results were obtained in allele frequency comparison among Chinese and Korean population for G-308A, G-238A and C-863A polymorphism. Although weak linkage disequilibrium was found between the markers tested, there were six haplotypes occurred in more than 1% of the population, with 308G/-863C/-238G as the most frequent haplotypes. Conclusion: This study recorded no association of TNF-α G-308A, C-863A and G-238A with two overweight/obesity phenotypes, BMI and WHR. Further studies with larger cohort and other obesity-related phenotypes are required to investigate the possible association of TNF-a polymorphism with overweight/obesity in Malaysian population. | en_US |
| dc.identifier.uri | https://hdl.handle.net/20.500.14377/32219 | |
| dc.language.iso | en | en_US |
| dc.publisher | International Medical University | en_US |
| dc.subject | Obesity | en_US |
| dc.subject | Overweight | en_US |
| dc.subject | Exercise | en_US |
| dc.subject | Energy Intake | en_US |
| dc.subject | Quality of Life | en_US |
| dc.title | ASSOCIATION OF GENOTYPES AND HAPLOTYPES OF TUMOUR NECROSIS FACTOR –ALPHA (TNF-α) WITH OVERWEIGHT/OBESITY-RELATED PHENOTYPES IN MALAYSIAN POPULATION | en_US |
| dc.type | Thesis | |
| dspace.entity.type | Publication |