Publication: SYNTHESIS, CHARACTERISATION, IN VITRO BIOLOGICAL EVALUATION AND MOLECULAR DOCKING OF A SERIES OF NOVEL 5-(SUBSTITUTED)-1,3- THIAZOLIDINE-2,4-DIONES AS POTENTIAL α-GLUCOSIDASE INHIBITORS
| dc.contributor.author | TAN LAY HSIEN | |
| dc.date.accessioned | 2023-10-06T15:20:57Z | |
| dc.date.available | 2023-10-06T15:20:57Z | |
| dc.date.issued | 2022 | |
| dc.description.abstract | α-Glucosidase is an intestinal membrane-bound enzyme that catalyze the final step in the digestion of carbohydrates. It cleaves the glycosidic bond of the oligosaccharides to release glucose and its inhibition results in a delayed glucose absorption and thereby inhibiting postprandial hyperglycemia and hyperinsulinemia in type 2 diabetic patients. Therefore, in view of the biological role of α-glucosidase as antidiabetic drug target, a series of six 5-(substituted)-1,3-thiazolidine-2,4-diones have been designed, synthesised and characterised by FT-IR, 1H NMR, 13C NMR and mass spectral analyses. All the compounds were subjected to the in vitro α-glucosidase inhibitory potential. Molecular docking studies have also been performed using the Schrödinger software “Glide module”. All compounds tested for the α- glucosidase inhibitory potential and all compounds exhibited significant inhibitions at IC50 values ranging from 0.0400 ± 0.3206 to 2.6847 ± 3.1441μM. Based on the molecular docking study, the binding properties (binding energy, binding orientation and binding interaction) of the ligandsrevealed the positive contribution of the 1,3-thiazolidine-2,4-dione moiety and phenyl ring substituents substituted at position 5 of 1,3-thiazolidine-2,4-dione towards the observed activity. Keywords: 5-(substituted)-1,3-thiazolidine-2,4-diones, α-glucosidase inhibitors, molecular docking | en_US |
| dc.identifier.uri | https://hdl.handle.net/20.500.14377/32071 | |
| dc.language.iso | en | en_US |
| dc.publisher | International Medical University | en_US |
| dc.subject | Glycoside Hydrolase Inhibitors | en_US |
| dc.subject | Hyperinsulinism | en_US |
| dc.subject | Diabetes Mellitus, Type 2 | en_US |
| dc.subject | Oligosaccharides | en_US |
| dc.subject | Molecular Docking Simulation | en_US |
| dc.title | SYNTHESIS, CHARACTERISATION, IN VITRO BIOLOGICAL EVALUATION AND MOLECULAR DOCKING OF A SERIES OF NOVEL 5-(SUBSTITUTED)-1,3- THIAZOLIDINE-2,4-DIONES AS POTENTIAL α-GLUCOSIDASE INHIBITORS | en_US |
| dc.type | Thesis | |
| dspace.entity.type | Publication |