Publication: SYNTHESIS AND BIOLOGICAL EVALUATION OF A SERIES OF BENZOTHIAZOLE ANALOGUES AS ANTIBACTERIAL AGENTS
| dc.contributor.author | GETHA A/P DASS | |
| dc.date.accessioned | 2024-03-08T14:00:40Z | |
| dc.date.available | 2024-03-08T14:00:40Z | |
| dc.date.issued | 2023 | |
| dc.description.abstract | The global crisis of antimicrobial resistance increases the demand for a potent antimicrobial agent. In the search for a novel class of antimicrobial agent, benzothiazole analogue has captured considerable attention as they proved to be promising drugs due to their outstanding antimicrobial activity against bacteria. In this study, a series of benzothiazole analogues (C1-C6) were synthesized and characterized by LC- MS, ATR FT-IR, and proton and carbon NMR spectroscopic techniques. All the synthesized compounds were examined for their in vitro antimicrobial activity against two types of bacterial strains: susceptible strains (Staphylococcus aureus ATCC 35923, Pseudomonas aeruginosa ATCC 27853, Escherichia coli ATCC 25922, Acinetobacter baumannii ATCC 19606) and resistant strains (Methicillin-resistant Staphylococcus aureus ATCC 43300, Pseudomonas aeruginosa ATCC BAA-2108, Escherichia coli ATCC BAA-196, Acinetobacter baumannii ATCC BAA-1797) using broth microdilution method and compared with drug-free control. The antimicrobial activities of the synthesised compounds were expressed as the minimum concentration (MIC) in μM and performed screening at a maximum concentration of 128 μM. Based on the report, all the synthesized compounds (C1-C6) displayed the highest concentration (MIC >128 μM) indicating poor antimicrobial activity against all eight bacterial strains. Therefore, it was concluded that the benzenesulfonylurea derivatisation on the benzothiazole ring system is unfavourable for the antibacterial properties. Keywords: Benzothiazole, in-vitro antimicrobial activity, MIC, microdilution | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14377/36067 | |
| dc.language.iso | en | |
| dc.publisher | International Medical University | |
| dc.subject | Anti-Infective Agents | |
| dc.subject | Spectrum Analysis | |
| dc.subject | Magnetic Resonance Spectroscopy | |
| dc.subject | Microbial Sensitivity Tests | |
| dc.subject | Drug Resistance, Microbial | |
| dc.title | SYNTHESIS AND BIOLOGICAL EVALUATION OF A SERIES OF BENZOTHIAZOLE ANALOGUES AS ANTIBACTERIAL AGENTS | |
| dc.type | Thesis | |
| dspace.entity.type | Publication | |
| oairecerif.author.affiliation | #PLACEHOLDER_PARENT_METADATA_VALUE# |