Publication:
EFFECT OF 14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE IN POLOXAMER-407 INDUCED ATHEROSCLEROSIS IN C57BL/6J MOUSE

Simple item page
dc.contributor.authorTAI ZHI SAM
dc.date.accessioned2023-10-06T15:20:52Z
dc.date.available2023-10-06T15:20:52Z
dc.date.issued2017
dc.description.abstractUsage of plant-based compounds has been increasing recently due to their unexpected efficacy in the mitigation of certain diseases, including atherosclerosis. The aims of this study are to investigate the potential anti-inflammatory and anti-oxidative effects of 14-deoxy-11,12-didehydroandrographolide (DDAGP), an Andrographis paniculata derivative, in C57BL/6J mouse model of atherosclerosis by determining relative NF-ĸB p65 and NOX-4 expression levels, in conjunction with biochemical profiling of plasma lipid and liver enzyme levels, in Poloxamer-407 (P-407) challenged C57BL/6J mouse model. Oral administration of DDAGP, with non-toxic concentration of 15 mg/kg/day, 30 mg/kg/day and 45 mg/kg/day, measurably reduced plasma lipid components, specifically LDL-c; but only the 45 mg/kg/day dose was conducive to significant TGL level reduction. Nevertheless, DDAGP did not significantly suppress the Atherogenic Index of Plasma (AIP) and the Atherogenic Coefficient (AC), suggesting that it lacks clinically significant anti-atherogenic ability. However, treatment of P-407 challenged mice with DDAGP significantly inhibited elevation of heart homogenate levels of NK-ĸB and NOX4 in a non-dose-dependent manner. Hence, even though DDAGP may not be an effective anti-atherogenic drug, it instead possesses marked anti-inflammatory and anti-oxidative potential. In conclusion, further research along these lines is warranted, with focus on DDAGP’s efficacy in the prophylaxis and management of inflammatory diseases.en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14377/32063
dc.language.isoenen_US
dc.publisherInternational Medical Universityen_US
dc.subjectPoloxameren_US
dc.subjectAtherosclerosisen_US
dc.subjectMiceen_US
dc.subjectAtherosclerosisen_US
dc.subjectOxidative Stressen_US
dc.subjectAcanthaceaeen_US
dc.titleEFFECT OF 14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE IN POLOXAMER-407 INDUCED ATHEROSCLEROSIS IN C57BL/6J MOUSEen_US
dc.typeThesis
dspace.entity.typePublication
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
TaiZhiSam.pdf
Size:
1.19 MB
Format:
Adobe Portable Document Format
Description:
Final Theses
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Plain Text
Description:
Download
Collections
Theses (MSc. Analytical & Pharmaceutical Chemistry)