Publication: METABOLIC RESPONSES TO ISOMALTULOSE BY MALAYSIAN CHINESE ADULTS: A PILOT STUDY
| dc.contributor.author | CHAN CHEE SHAN | |
| dc.date.accessioned | 2023-10-06T15:25:16Z | |
| dc.date.available | 2023-10-06T15:25:16Z | |
| dc.date.issued | 2017 | |
| dc.description.abstract | Isomaltulose is a disaccharide in which glucose is α- 1,6 linked to fructose. The capacity of fasted Malaysian adults to tolerate boluses of isomaltulose (25 g, 50 g, 75 g, 100 g) was investigated by serial measurements of breath hydrogen. A response of > 20 ppm was considered to indicate spill-over of isomaltulose to the colon. Twenty-eight consenting participants [10 males, 18 females, 20 - 36 years of age, with body mass index (BMI) ranging from 15 – 31 kg/m2] underwent crossover studies using a portable apparatus over five hours. 9/25 (36 %) participants gave evidence of spill-over at 75 g and 19/28 (70 %) to 100 g of isomaltulose. In 6 males and 11 females, glycaemic responses were compared to sucrose with a two-week washout period. The blood glucose response to isomaltulose (6.6 ± 0.9 SD mmol/L) was significantly lower than to the same bolus of sucrose (8.7 ± 1.8 SD mmol/L; p = 0.001). Faecal pH changes were measured to test for possible prebiotic effects. After a bolus of 75 g of isomaltulose, the acidity of both the first and second subsequent faecal samples was significantly greater than pre-test samples, suggesting that isomaltulose may possess a prebiotic potential. The finding of intolerance to isomaltulose suggests that caution should be exercised in its use as a carbohydrate nutrient. | en_US |
| dc.identifier.uri | https://hdl.handle.net/20.500.14377/32106 | |
| dc.language.iso | en | en_US |
| dc.publisher | International Medical University | en_US |
| dc.subject | Adult | en_US |
| dc.subject | Blood Glucose | en_US |
| dc.subject | Body Mass Index | en_US |
| dc.subject | Colon | en_US |
| dc.subject | Prebiotics | en_US |
| dc.subject | Overweight | en_US |
| dc.subject | Obesity | en_US |
| dc.title | METABOLIC RESPONSES TO ISOMALTULOSE BY MALAYSIAN CHINESE ADULTS: A PILOT STUDY | en_US |
| dc.type | Thesis | |
| dspace.entity.type | Publication |