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SYNTHESIS, CHARACTERISATION, AND IN VITRO BIOLOGICAL EVALUATION OF A SERIES OF NOVEL BENZOTHIAZOLE DERIVATIVES AS ANTIBACTERIAL AGENTS

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dc.contributor.authorHADYAH MOHAMMED ALAZMAA
dc.date.accessioned2023-10-06T15:32:11Z
dc.date.available2023-10-06T15:32:11Z
dc.date.issued2021
dc.description.abstractA group of benzothiazole-amide derivatives (VH01-06) were conventionally synthesised in using modified reaction conditions of the Schotten-Baumann named reaction, all the synthesised compounds were characterised using physical methods such as Thin-layer chromatography to determine the retention factor and melting point. All the chemical structure of the compounds were consistently with the spectral data obtained for FT-IR, 1H & 13C NMR and HRMS ESI-Mass spectroscopic techniques. These compounds were further exposed to in vitro antibacterial activity screening various strains includes gram-positive bacteria (Methicillin-resistant Staphylococcus aureus (MRSA) ATCC 3359 and Methicillinsensitive Staphylococcus aureus (MSSA) ATCC 2592 and gram-negative bacteria (Escherichia coli J53 R1, Escherichia coli ATCC 25922, Klebsiella pneumoniae ATCC 10031 and Klebsiella pneumonia BAA-1075). Based on the screening results, the benzothiazole compounds were appeared to be active at 100μM concentration. However, one compound was reported as active against E. coli ATCC 25923 at 200 μg/mL. Keywords: Benzothiazole, in vitro antibacterial activity.en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14377/32218
dc.language.isoenen_US
dc.publisherInternational Medical Universityen_US
dc.subjectIn Vitro Techniquesen_US
dc.subjectBenzothiazolesen_US
dc.subjectChromatography, Thin Layeren_US
dc.subjectMethicillin-Resistant Staphylococcus aureusen_US
dc.subjectEscherichia colien_US
dc.subjectKlebsiella pneumoniaeen_US
dc.titleSYNTHESIS, CHARACTERISATION, AND IN VITRO BIOLOGICAL EVALUATION OF A SERIES OF NOVEL BENZOTHIAZOLE DERIVATIVES AS ANTIBACTERIAL AGENTSen_US
dc.typeThesis
dspace.entity.typePublication
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