Publication: CATALYST-FREE SYNTHESIS OF A SERIES OF DIARYLSUFONYLUREAS
Date
2023
Authors
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Journal ISSN
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Publisher
International Medical University
Abstract
In comparison to traditional organic synthesis, catalyst-free synthetic techniques provide several
advantages and have been proved to be environmentally friendly. Here, a facile catalyst-free
procedure for the synthesis of derivatives of diarylsulfonylureas was developed. The simple
process involves reacting p-toluenesulfonyl isocyanate with various substituted primary amines in
the presence of dichloromethane as the solvent at room temperature to produce the desired
diarylsulfonylureas derivatives. Nine compounds with up to 94% yield have been synthesized
successfully through this protocol. These products' structures were characterised using a variety of
techniques, including fourier-transform infrared spectroscopy, mass spectroscopy, nuclear
magnetic resonance spectroscopy, physical analysis, and melting point. Overall, this method has
many benefits, including convenient room temperature synthesis, a straightforward workup
procedure, rapid reaction times, and quantifiable reaction yields.
Keywords: Diarylsulfonylureas, Green Chemistry, Catalyst-Free, Room Temperature synthesis
Description
Keywords
Chemistry Techniques, Synthetic, Magnetic Resonance Spectroscopy, Spectroscopy, Fourier Transform Infrared, Environmental Pollutants, Photosynthesis